Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.

نویسندگان

  • A A Rossini
  • J P Mordes
  • A M Pelletier
  • A A Like
چکیده

Weekly transfusions of whole blood from a nondiabetic subline of BB/W rats reduced the incidence of diabetes in susceptible BB/W rats from 39 to 0 percent and the incidence of pancreatic insulitis from 64 to 6 percent. Responsiveness of lymphocytes to concanavalin A was found to be low in rats with diabetes or insulitis. Transfusion restored concanavalin A responsiveness to levels observed in control rats free of diabetes or insulitis. These data suggest that whole blood alters the course of autoimmune BB/W rat diabetes.

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عنوان ژورنال:
  • Science

دوره 219 4587  شماره 

صفحات  -

تاریخ انتشار 1983